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Antimicrobial Agents and Chemotherapy, February 2003, p. 794-797, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.794-797.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genetic Basis of Antibiotic Resistance in Streptococcus agalactiae Strains Isolated in a French Hospital

Claire Poyart,1,2,3* Laurence Jardy,2 Gilles Quesne,2 Patrick Berche,2,3 and Patrick Trieu-Cuot1,3

Laboratoire Mixte Pasteur-Necker de Recherche sur les Streptocoques et Streptococcies, Faculté de Médecine Necker-Enfants Malades, 75730 Paris Cedex 15,1 Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades,2 INSERM U570, Faculté de Médecine, Necker-Enfants Malades, 75015 Paris, France3

Received 8 July 2002/ Returned for modification 14 October 2002/ Accepted 15 November 2002

The genetic basis of antibiotic resistance in 113 unrelated group B streptococci was studied by PCR. Ninety-four strains were resistant to tetracycline-minocycline, and tet(M) was detected in 85% of these isolates. Seventeen erythromycin-resistant strains contained the erm(B), erm(TR), or mef(A) gene. Eleven strains exhibited high-level resistance to kanamycin due to the presence of the aphA3 gene; eight of these strains were also highly resistant to streptomycin; aad-6-related sequences were detected in seven strains.

* Corresponding author. Mailing address: Laboratoire Mixte Pasteur-Necker de Recherche sur les Streptocoques et Streptococcies, Faculté de Médecine Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France. Phone: (33) (1) 40 61 56 79. Fax: (33) (1) 40 61 55 92. E-mail: poyart{at}necker.fr.

Antimicrobial Agents and Chemotherapy, February 2003, p. 794-797, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.794-797.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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