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Antimicrobial Agents and Chemotherapy, February 2003, p. 800-803, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.800-803.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Growth-Inhibitory Effects of Artesunate, Pyrimethamine, and Pamaquine against Babesia equi and Babesia caballi in In Vitro Cultures

Akiko Nagai,1 Naoaki Yokoyama,1 Tomohide Matsuo,1 Sabine Bork,1 Haruyuki Hirata,1 Xuenan Xuan,1 Yinchang Zhu,2 Florencia G. Claveria,1 Kozo Fujisaki,1 and Ikuo Igarashi1*

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine Obihiro, Hokkaido 080-8555, Japan,1 Jiangsu Institute of Parasitic Disease, Meiyua, Wuzi 214064, Jiangsu, People's Republic of China2

Received 6 May 2002/ Returned for modification 28 August 2002/ Accepted 5 November 2002

Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in vivo effectiveness.

* Corresponding author. Mailing address: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Phone: 81-155-49-5641. Fax: 81-155-49-5643. E-mail: igarcpmi{at}obihiro.ac.jp.

Antimicrobial Agents and Chemotherapy, February 2003, p. 800-803, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.800-803.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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