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Antimicrobial Agents and Chemotherapy, February 2003, p. 804-808, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.804-808.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology of Penicillin-Resistant and Ciprofloxacin-Resistant Streptococcus pneumoniae in Canada

Kimberly A. Nichol,1,2* George G. Zhanel,1,2,3 and Daryl J. Hoban1,2

Department of Medical Microbiology, Faculty of Medicine, University of Manitoba,1 Departments of Medicine,3 Clinical Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada2

Received 15 July 2002/ Returned for modification 25 August 2002/ Accepted 7 November 2002

Eighty-nine penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae isolates were evaluated by serotyping and pulsed-field gel electrophoresis. Although penicillin-resistant isolates demonstrated considerable homogeneity, resistance to ciprofloxacin did not correlate with a reduction in genotypic variability. These results suggest that, unlike that of penicillin resistance, the spread of S. pneumoniae ciprofloxacin resistance in Canada is currently not attributable to clonal dissemination.

* Corresponding author. Mailing address: Clinical Microbiology, Health Sciences Centre, MS673—820 Sherbrook St., Winnipeg, Manitoba, R3A 1R9, Canada. Phone: (204) 787-4684. Fax: (204) 787-4699. E-mail: knichol{at}hsc.mb.ca.

Antimicrobial Agents and Chemotherapy, February 2003, p. 804-808, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.804-808.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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