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Antimicrobial Agents and Chemotherapy, February 2003, p. 820-823, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.820-823.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae

Jianzhong Liu,1,2* Ki-Fai Fung,1 Zhangliu Chen,1 Zhenling Zeng,1 and Jie Zhang1,3

Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China,1 Division of Pharmacology and Clinical Pharmacology,2 Department of Molecular Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand3

Received 8 April 2002/ Returned for modification 3 September 2002/ Accepted 31 October 2002

A comparative in vivo pharmacokinetic study of florfenicol was conducted in 18 crossbred pigs infected with Actinobacillus pleuropneumoniae following intravenous (i.v.), intramuscular (i.m.), or oral (p.o.) administration of a single dose of 20 mg/kg. The disease model was confirmed by clinical signs, X rays, pathohistologic examinations, and organism isolation. Florfenicol concentrations in plasma were determined by a validated high-performance liquid chromatography method with UV detection at a wavelength of 223 nm. Pharmacokinetic parameters were calculated by using the MCPKP software (Research Institute of Traditional Chinese Veterinary Medicine, Lanzhou, China). The disposition of florfenicol after a single i.v. bolus was described by a two-compartment model with values for the half-life at {alpha} phase (t1/2{alpha}), the half-life at ß phase (t1/2ß), the area under the concentration-time curve (AUC0-{infty}), and the volume of distribution at steady state (Vss) of 0.37 h, 2.91 h, 64.86 µg · h/ml, and 1.2 liter/kg, respectively. The concentration-time data fitted the one-compartment (after i.m.) and two-compartment (after p.o.) models with first-order absorption. The values for the maximum concentration of drug in serum (Cmax), t1/2{alpha}, t1/2ß, and bioavailability after i.m. and p.o. dosing were 4.00 and 8.11 µg/ml, 0.12 and 3.91 h, 13.88 and 16.53 h, and 122.7 and 112.9%, respectively, for the two models. The study showed that florfenicol was absorbed quickly and completely, distributed widely, and eliminated slowly in the infected pigs, and there was no statistically significant difference between the pharmacokinetic profiles for the infected and healthy pigs.

* Corresponding author. Mailing address: Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, The University of Auckland, Park Rd., Grafton, Auckland, New Zealand. Phone: 0064 (16) 3737599, ext. 86410. Fax: 0064 (9) 3737556. E-mail: j.liu{at}auckland.ac.nz.

Antimicrobial Agents and Chemotherapy, February 2003, p. 820-823, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.820-823.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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