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Antimicrobial Agents and Chemotherapy, March 2003, p. 1112-1114, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1112-1114.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Erythromycin and Clindamycin Resistance and Telithromycin Susceptibility in Streptococcus agalactiae

C. Betriu,* E. Culebras, M. Gómez, I. Rodríguez-Avial, B. A. Sánchez, M. C. Ágreda, and J. J. Picazo

Department of Clinical Microbiology, Hospital Clínico San Carlos, 28040 Madrid, Spain

Received 19 September 2002/ Returned for modification 25 October 2002/ Accepted 24 November 2002

The rates of resistance to erythromycin and clindamycin among Streptococcus agalactiae strains isolated in our hospital increased from 4.2 and 0.8% in 1993 to 17.4 and 12.1%, respectively, in 2001. Erythromycin resistance was mainly due to the presence of an Erm(B) methylase, while the M phenotype was detected in 3.8% of the strains. Telithromycin was very active against erythromycin-resistant strains, irrespective of their mechanisms of macrolide resistance.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Hospital Clínico San Carlos, Plaza Cristo Rey s/n, 28040 Madrid, Spain. Phone: 34 913303486. Fax: 34 913303478. E-mail: cbetriu{at}efd.net.

Antimicrobial Agents and Chemotherapy, March 2003, p. 1112-1114, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1112-1114.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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