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Antimicrobial Agents and Chemotherapy, March 2003, p. 1132-1134, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1132-1134.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Bactericidal Activities of ABT-773 against ermB Strains of Streptococcus pneumoniae

Melinda M. Neuhauser,1 Jennifer L. Prause,2 Larry H. Danziger,2 and Susan L. Pendland2*

Department of Clinical Sciences and Administration, The University of Houston College of Pharmacy, Houston, Texas,1 Department of Pharmacy Practice, Microbiology Research Laboratory, The University of Illinois at Chicago, Chicago, Illinois2

Received 3 December 2001/ Returned for modification 17 August 2002/ Accepted 15 November 2002

The bactericidal activities of ABT-773, a new ketolide, were compared to those of cefuroxime and amoxicillin-clavulanate against 10 strains of Streptococcus pneumoniae containing the ermB gene. MICs and time-kill curves were determined in duplicate per NCCLS guidelines with cation-adjusted Mueller-Hinton broth with 3% lysed horse blood. Viable counts were done at 0, 2, 6, and 24 h. Antibiotic concentrations tested were two and eight times the MIC. ABT-773 MICs ranged from 0.008 to 1.0 µg/ml. Bactericidal activity was observed with ABT-773 at eight times the MIC against 4 of 10 strains at 24 h compared to 10 of 10 strains with the beta-lactam antibiotics.

* Corresponding author. Mailing address: The University of Illinois at Chicago, College of Pharmacy, Department of Pharmacy Practice (M/C 886), 833 South Wood St., Chicago, IL 60612. Phone: (312) 996-8639. Fax: (312) 413-1797. E-mail: pendland{at}uic.edu.

Antimicrobial Agents and Chemotherapy, March 2003, p. 1132-1134, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1132-1134.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Azoulay-Dupuis, E., Mohler, J., Bedos, J. P., Barau, C., Fantin, B. (2006). Efficacy of Cethromycin, a New Ketolide, against Streptococcus pneumoniae Susceptible or Resistant to Erythromycin in a Murine Pneumonia Model.. Antimicrob. Agents Chemother. 50: 3033-3038 [Abstract] [Full Text]  
  • Labro, M. T., Abdelghaffar, H., Babin-Chevaye, C. (2004). Interaction of the New Ketolide ABT-773 (Cethromycin) with Human Polymorphonuclear Neutrophils and the Phagocytic Cell Line PLB-985 In Vitro. Antimicrob. Agents Chemother. 48: 1096-1104 [Abstract] [Full Text]  


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