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Antimicrobial Agents and Chemotherapy, March 2003, p. 1154-1156, Vol. 47, No. 3
0066-4804/03/$08.00+0 DOI: 10.1128/AAC.47.3.1154-1156.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
Vancomycin Resistance Is Maintained in Enterococci in the Viable but Nonculturable State and after Division Is Resumed
Maria del Mar Lleò,* Barbara Bonato, Caterina Signoretto, and Pietro Canepari
Dipartimento di PatologiaSezione di Microbiologia, Università di Verona, 37134 Verona, Italy
Received 9 July 2002/
Returned for modification 8 October 2002/
Accepted 4 December 2002
Stressed vancomycin-resistant enterococci (VRE) can activate a survival strategy known as the viable but nonculturable (VBNC) state and are able to maintain vancomycin resistance. During restoration of division they continue to express the vancomycin resistance trait. We suggest that VBNC enterococci may constitute further reservoirs of VRE and therefore represent an additional risk for human health.
* Corresponding author. Mailing address: Dipartimento di Patologia, Sezione di Microbiologia, Università di Verona, Strada Le Grazie 8, 37134 Verona, Italy. Phone: 39 045 8027194. Fax: 39 045 584606. E-mail:
mlleo{at}univr.it.
Antimicrobial Agents and Chemotherapy, March 2003, p. 1154-1156, Vol. 47, No. 3
0066-4804/03/$08.00+0 DOI: 10.1128/AAC.47.3.1154-1156.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
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