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Antimicrobial Agents and Chemotherapy, March 2003, p. 1169-1172, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1169-1172.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

A New Sulfonamide Resistance Gene (sul3) in Escherichia coli Is Widespread in the Pig Population of Switzerland

Vincent Perreten* and Patrick Boerlin*

Institute of Veterinary Bacteriology, University of Bern, CH-3012 Bern, Switzerland

Received 30 July 2002/ Returned for modification 9 October 2002/ Accepted 21 November 2002

A new gene, sul3, which specifies a 263-amino-acid protein similar to a dihydropteroate synthase encoded by the 54-kb conjugative plasmid pVP440 from Escherichia coli was characterized. Expression of the cloned sul3 gene conferred resistance to sulfamethoxazole on E. coli. Two copies of the insertion element IS15{Delta}/26 flanked the region containing sul3. The sul3 gene was detected in one-third of the sulfonamide-resistant pathogenic E. coli isolates from pigs in Switzerland.

* Corresponding author. Mailing address for Vincent Perreten: Institute of Veterinary Bacteriology, University of Bern, Längass-Strasse 122, CH-3012 Bern, Switzerland. Phone: 41 31 631 2435. Fax: 41 31 631 2634. E-mail: vincent.perreten{at}vbi.unibe.ch. Present address for Patrick Boerlin: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Phone: (519) 824-4120. Fax: (519) 824-5930. E-mail: pboerlin{at}uoguelph.ca.

Antimicrobial Agents and Chemotherapy, March 2003, p. 1169-1172, Vol. 47, No. 3
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.3.1169-1172.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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