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Antimicrobial Agents and Chemotherapy, April 2003, p. 1297-1300, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1297-1300.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Imipenem Resistance in a Salmonella Clinical Strain Due to Plasmid-Mediated Class A Carbapenemase KPC-2

Vivi Miriagou,1 Leonidas S. Tzouvelekis,2 Shannon Rossiter,3 Eva Tzelepi,1 Frederick J. Angulo,3 and Jean M. Whichard3*

Laboratory of Bacteriology, Hellenic Pasteur Institute,1 Department of Microbiology, Medical School, University of Athens, Athens, Greece,2 Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia3

Received 29 July 2002/ Returned for modification 24 October 2002/ Accepted 2 January 2003

A Salmonella enterica serotype Cubana isolate exhibiting resistance to most ß-lactam antibiotics, including oxyimino-cephalosporins and imipenem, was isolated from a 4-year-old boy with gastroenteritis in Maryland. ß-Lactam resistance was mediated by a conjugative plasmid that encoded KPC-2, a class A carbapenemase previously found in a Klebsiella pneumoniae isolate from the Maryland area as well. Sequence analysis of the flanking regions indicated a potential association of blaKPC-2 with mobile structures.

* Corresponding author. Mailing address: National Center for Infectious Diseases, MS G29, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-2000. Fax: (404) 639-4290. E-mail: zyr3{at}cdc.gov.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1297-1300, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1297-1300.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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