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Antimicrobial Agents and Chemotherapy, April 2003, p. 1407-1409, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1407-1409.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Metronidazole and Tinidazole Activities against Metronidazole- Resistant Strains of Trichomonas vaginalis

Andrea L. Crowell,1 Kolby A. Sanders-Lewis,1,2 and W. Evan Secor1*

Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Servicesthe,1 Atlanta Research and Education Foundation, VA Medical Center, Atlanta, Georgia2

Received 28 October 2002/ Returned for modification 2 December 2002/ Accepted 7 January 2003

The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.

* Corresponding author. Mailing address: Immunology Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724. Phone: (770) 488-4115. Fax: (770) 488-4108. E-mail: was4{at}cdc.gov.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1407-1409, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1407-1409.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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