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Genetic Characterization of Fluoroquinolone-Resistant Streptococcus pneumoniae Strains Isolated during Ciprofloxacin Therapy from a Patient with Bronchiectasis

Adela G. de la Campa,^1* María-José Ferrandiz,^1, Fe Tubau,² Román Pallarés,³ Federico Manresa,⁴ and Josefina Liñares²

Unidad de Genética Bacteriana (Consejo Superior de Investigaciones Científicas), Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid,¹ Servicio de Microbiología,² Servicio de Enfermedades Infecciosas,³ Servicio de Neumología, Hospital de Bellvitge and Universidad de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain⁴

Received 20 September 2002/ Returned for modification 13 November 2002/ Accepted 15 January 2003

Five Spain^9V-3 Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants.

Present address: Institute of Infection and Immunity, Nottingham, United Kingdom.

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