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Antimicrobial Agents and Chemotherapy, April 2003, p. 1427-1429, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1427-1429.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Integron-Associated Antibiotic Resistance in Salmonella enterica Serovar Typhi from Asia

Marie-Cécile Ploy,1* Delphine Chainier,1 Nhu Hoa Tran Thi,2 Isabelle Poilane,2 Philippe Cruaud,2 François Denis,1 Anne Collignon,2,3 and Thierry Lambert3

Laboratoire de Bactériologie-Virologie-Hygiène, CHU Dupuytren, Limoges,1 Laboratoire de Microbiologie, CHU Jean Verdier, Paris,2 Laboratoire de Microbiologie, Faculté de Pharmacie, ChÂtenay-Malabry, France3

Received 15 October 2002/ Returned for modification 6 December 2002/ Accepted 20 January 2003

Eighteen of 25 isolates of Salmonella enterica serovar Typhi were multidrug resistant and contained class 1 integrons with a single cassette, dfrVII or aadA1. The dfrVII-containing integron was likely borne on an IncHI1 plasmid. Salmonella serovar Typhi could become resistant to broad-spectrum cephalosporins by integrating cassettes, such as veb-1, a common cassette in Asia.

* Corresponding author. Mailing address: Laboratoire de Bactériologie-Virologie-Hygiène, CHU Dupuytren, 2, avenue Martin Luther King, 87042 Limoges Cedex, France. Phone: (33) (5) 55 05 61 66. Fax: (33) (5) 55 05 67 22. E-mail: marie-cecile.ploy{at}unilim.fr.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1427-1429, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1427-1429.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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