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Antimicrobial Agents and Chemotherapy, April 2003, p. 1430-1432, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1430-1432.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Novel Tetracycline Resistance Determinant from the Oral Metagenome

M. L. Diaz-Torres,1 R. McNab,1,{dagger} D. A. Spratt,1 A. Villedieu,1 N. Hunt,2 M. Wilson,1 and P. Mullany1*

Department of Microbiology,1 Department of Orthodontics, Eastman Dental Institute, University College London, London, United Kingdom2

Received 7 October 2002/ Returned for modification 27 November 2002/ Accepted 23 January 2003

A major drawback of most studies on how bacteria become resistant to antibiotics is that they concentrate mainly on bacteria that can be cultivated in the laboratory. In the present study, we cloned part of the oral metagenome and isolated a novel tetracycline resistance gene, tet(37), which inactivates tetracycline.

* Corresponding author. Mailing address: Department of Microbiology, Eastman Dental Institute, University College London, 256 Gray's Inn Rd., London WC1X 8LD, United Kingdom. Phone: 44 0 20 7915 1223. Fax: 44 0 20 7915 1127. E-mail: p.mullany{at}eastman.ucl.ac.uk.

{dagger} Present address: GlaxoSmithKline Consumer Healthcare, Surrey, United Kingdom.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1430-1432, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1430-1432.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kazimierczak, K. A., Rincon, M. T., Patterson, A. J., Martin, J. C., Young, P., Flint, H. J., Scott, K. P. (2008). A New Tetracycline Efflux Gene, tet(40), Is Located in Tandem with tet(O/32/O) in a Human Gut Firmicute Bacterium and in Metagenomic Library Clones. Antimicrob. Agents Chemother. 52: 4001-4009 [Abstract] [Full Text]  
  • Gloux, K., Leclerc, M., Iliozer, H., L'Haridon, R., Manichanh, C., Corthier, G., Nalin, R., Blottiere, H. M., Dore, J. (2007). Development of High-Throughput Phenotyping of Metagenomic Clones from the Human Gut Microbiome for Modulation of Eukaryotic Cell Growth. Appl. Environ. Microbiol. 73: 3734-3737 [Abstract] [Full Text]  
  • Handelsman, J. (2004). Metagenomics: Application of Genomics to Uncultured Microorganisms. Microbiol. Mol. Biol. Rev. 68: 669-685 [Abstract] [Full Text]  


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