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Antimicrobial Agents and Chemotherapy, April 2003, p. 1436-1438, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1436-1438.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activity of Posaconazole against Pseudallescheria boydii: In Vitro and In Vivo Assays

Gloria M. González,1,2* Rolando Tijerina,2 Laura K. Najvar,1 Rosie Bocanegra,1 Michael G. Rinaldi,3,4 David Loebenberg,5 and John R. Graybill1

Division of Infectious Diseases (7881), Department of Medicine,1 Department of Pathology, The University of Texas Health Science Center at San Antonio,3 Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78229-3900,4 Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México,2 Schering-Plough Research Institute, Kenilworth, New Jersey 07033-05305

Received 15 May 2002/ Returned for modification 13 June 2002/ Accepted 28 January 2003

Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.

* Corresponding author. Mailing address: Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Madero y Dr. Eduardo A. Pequeño s/n, Colonia Mitras Centro, Monterrey, Nuevo León, México 64460. Phone: (52) 8329 4166. Fax: (52) 8348 5477. E-mail: gmglez{at}yahoo.com.mx.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1436-1438, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1436-1438.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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