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Antimicrobial Agents and Chemotherapy, April 2003, p. 1460-1463, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1460-1463.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

mecA-blaZ Corepressors in Clinical Staphylococcus aureus Isolates

Adriana E. Rosato,1 Barry N. Kreiswirth,2 William A. Craig,1 William Eisner,2 Michael W. Climo,1,3 and Gordon L. Archer1,4*

Departments of Medicine,1 Microbiology and Immunology, Medical College of Virginia Campus of Virginia Commonwealth University,4 Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia,3 the Public Health Research Institute, Newark, New Jersey2

Received 9 September 2002/ Returned for modification 19 November 2002/ Accepted 2 January 2003

The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI was present in only 21 of 28 (78%) isolates with wild-type mecI (P < 0.05). Among 22 additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude that oxacillin-resistant S. aureus must have at least one of the two functional mecA regulators.

* Corresponding author. Mailing address: Department of Medicine, Medical College of Virginia, 1101 East Marshall St., Richmond, VA 23298-0049. Phone: (804) 828-9711. Fax: (804) 827-1749. E-mail: garcher{at}hsc.vcu.edu.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1460-1463, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1460-1463.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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