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Antimicrobial Agents and Chemotherapy, April 2003, p. 1476-1478, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1476-1478.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Pathogenic Nocardia, Rhodococcus, and Related Organisms Are Highly Susceptible to Imidazole Antifungals

Eric R. Dabbs,* Samantha Naidoo, Catherine Lephoto, and Natalya Nikitina

School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa

Received 8 May 2002/ Returned for modification 3 July 2002/ Accepted 27 January 2003

Rhodococcus equi and species of Nocardia and Gordonia may be human opportunistic pathogens. We find that these, as well as several isolates from closely related genera, are highly susceptible to the imidazoles bifonazole, clotrimazole, econazole, and miconazole, whose MICs are <=1 µg/ml. In liquid cultures 1 µg of the drug/ml was bacteriostatic and 10 µg/ml was bactericidal. On solid media at 10 µg of azole/ml no resistant mutants could be isolated. An MIC of 1 to 15 µg/ml was observed with ketoconazole, whereas none of these organisms was inhibited by the triazoles fluconazole and voriconazole (100 µg/ml). Imidazoles may offer the prospect of treatment of nocardioform mycetomas and may provide the basis for the development of additional antimicrobial agents to combat these pathogens.

* Corresponding author. Mailing address: School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg P O WITS 2050, South Africa. Phone: 27 11 717 6364. Fax: 27 11 403 1733. E-mail: dabbse{at}gecko.biol.wits.ac.za.

Antimicrobial Agents and Chemotherapy, April 2003, p. 1476-1478, Vol. 47, No. 4
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.4.1476-1478.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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