This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sahly, H.
Right arrow Articles by Podschun, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sahly, H.
Right arrow Articles by Podschun, R.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2003, p. 1739-1741, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1739-1741.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Burkholderia Is Highly Resistant to Human Beta-Defensin 3

Hany Sahly,1* Sabine Schubert,1 Jürgen Harder,2 Peter Rautenberg,1 Uwe Ullmann,1 Jens Schröder,2 and Rainer Podschun1

Department of Medical Microbiology and Virology,1 Clinical Research Unit, Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany2

Received 31 October 2002/ Returned for modification 9 December 2002/ Accepted 29 January 2003

The bactericidal activity of the novel beta-defensin hBD-3 against 28 species and 55 strains of gram-positive cocci and gram-negative fermentative and nonfermentative rods was tested. All strains proved to be highly or intermediately susceptible to hBD-3 (minimal bactericidal concentration [MBC], <=50 µg/ml), except for Burkholderia cepacia, for all 23 tested strains of which MBCs were >100 µg/ml.

* Corresponding author. Mailing address: Department of Medical Microbiology and Virology, University Hospital Schleswig-Holstein, Campus Kiel, Brunswiker Str. 4, 24105 Kiel, Germany. Phone: 49 431 597 3316. Fax: 49 431 597 3296. E-mail: sahly{at}medmicrobio.uni-kiel.de.

Antimicrobial Agents and Chemotherapy, May 2003, p. 1739-1741, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1739-1741.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Augustin, R., Anton-Erxleben, F., Jungnickel, S., Hemmrich, G., Spudy, B., Podschun, R., Bosch, T. C. G. (2009). Activity of the Novel Peptide Arminin against Multiresistant Human Pathogens Shows the Considerable Potential of Phylogenetically Ancient Organisms as Drug Sources. Antimicrob. Agents Chemother. 53: 5245-5250 [Abstract] [Full Text]  
  • Kooi, C., Sokol, P. A. (2009). Burkholderia cenocepacia zinc metalloproteases influence resistance to antimicrobial peptides. Microbiology 155: 2818-2825 [Abstract] [Full Text]  
  • Ortega, X., Silipo, A., Saldias, M. S., Bates, C. C., Molinaro, A., Valvano, M. A. (2009). Biosynthesis and Structure of the Burkholderia cenocepacia K56-2 Lipopolysaccharide Core Oligosaccharide: TRUNCATION OF THE CORE OLIGOSACCHARIDE LEADS TO INCREASED BINDING AND SENSITIVITY TO POLYMYXIN B. J. Biol. Chem. 284: 21738-21751 [Abstract] [Full Text]  
  • Jung, S., Dingley, A. J., Augustin, R., Anton-Erxleben, F., Stanisak, M., Gelhaus, C., Gutsmann, T., Hammer, M. U., Podschun, R., Bonvin, A. M. J. J., Leippe, M., Bosch, T. C. G., Grotzinger, J. (2009). Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra. J. Biol. Chem. 284: 1896-1905 [Abstract] [Full Text]  
  • Hinrichsen, K., Podschun, R., Schubert, S., Schroder, J. M., Harder, J., Proksch, E. (2008). Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3. Antimicrob. Agents Chemother. 52: 1876-1879 [Abstract] [Full Text]  
  • Harder, J., Glaser, R., Schroder, J.-M. (2007). Review: Human antimicrobial proteins effectors of innate immunity. Innate Immunity 13: 317-338 [Abstract]  
  • Taylor, K., McCullough, B., Clarke, D. J., Langley, R. J., Pechenick, T., Hill, A., Campopiano, D. J., Barran, P. E., Dorin, J. R., Govan, J. R. W. (2007). Covalent Dimer Species of {beta}-Defensin Defr1 Display Potent Antimicrobial Activity against Multidrug-Resistant Bacterial Pathogens. Antimicrob. Agents Chemother. 51: 1719-1724 [Abstract] [Full Text]  
  • Rudolph, B., Podschun, R., Sahly, H., Schubert, S., Schroder, J. M., Harder, J. (2006). Identification of RNase 8 as a Novel Human Antimicrobial Protein.. Antimicrob. Agents Chemother. 50: 3194-3196 [Abstract] [Full Text]  
  • Sahly, H., Schubert, S., Harder, J., Kleine, M., Sandvang, D., Ullmann, U., Schroder, J. M., Podschun, R. (2006). Activity of human {beta}-defensins 2 and 3 against ESBL-producing Klebsiella strains. J Antimicrob Chemother 57: 562-565 [Abstract] [Full Text]  
  • Harder, J., Schroder, J.-M. (2005). Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins. J. Leukoc. Biol. 77: 476-486 [Abstract] [Full Text]  
  • De Soyza, A., Ellis, C. D., Khan, C. M. A., Corris, P. A., de Hormaeche, R. D. (2004). Burkholderia cenocepacia Lipopolysaccharide, Lipid A, and Proinflammatory Activity. Am. J. Respir. Crit. Care Med. 170: 70-77 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»