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Antimicrobial Agents and Chemotherapy, May 2003, p. 1742-1745, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1742-1745.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibilities of Rhodococcus equi and Other Common Equine Pathogens to Azithromycin, Clarithromycin, and 20 Other Antimicrobials

Department of Large Animal Clinical Sciences,¹ Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610-0136²

Received 10 May 2002/ Returned for modification 8 January 2003/ Accepted 4 February 2003

The objective of this study was to determine in vitro activities of azithromycin (AZM), clarithromycin (CLR), and 20 other antimicrobial agents against Rhodococcus equi and other common equine bacterial pathogens. A total of 201 bacterial isolates from various equine clinical samples were examined. CLR was more active than AZM against R. equi, with MICs at which 90% of the isolates were inhibited of 0.12 and 1.0 µg/ml, respectively. Other antimicrobial agents highly active against at least 90% of R. equi isolates in vitro included rifampin, gentamicin, and imipenem. Both AZM and CLR showed good activity against beta-hemolytic streptococci and Staphylococcus spp. AZM was more active than other macrolides against Pasteurella spp. and Salmonella enterica.