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Antimicrobial Agents and Chemotherapy, May 2003, p. 1746-1748, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1746-1748.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Novel 3-N-Aminoglycoside Acetyltransferase Gene, aac(3)-Ic, from a Pseudomonas aeruginosa Integron

Maria Letizia Riccio,1 Jean-Denis Docquier,1 Emanuela Dell'Amico,1 Francesco Luzzaro,2 Gianfranco Amicosante,3 and Gian Maria Rossolini1*

Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena,1 Laboratorio di Microbiologia, Ospedale di Circolo di Varese, I-21100, Varese,2 Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, I-67100, L'Aquila, Italy3

Received 23 October 2002/ Returned for modification 16 December 2002/ Accepted 27 January 2003

A novel gene, aac(3)-Ic, encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a blaVIM-2 and a cmlA7 gene cassette. The aac(3)-Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.

* Corresponding author. Mailing address: Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Policlinico Le Scotte, 53100 Siena, Italy. Phone: 39 0577 233327. Fax: 39 0577 233325. E-mail: rossolini{at}unisi.it.

Antimicrobial Agents and Chemotherapy, May 2003, p. 1746-1748, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1746-1748.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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