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Antimicrobial Agents and Chemotherapy, May 2003, p. 1752-1755, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1752-1755.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Influences of Linezolid, Penicillin, and Clindamycin, Alone and in Combination, on Streptococcal Pyrogenic Exotoxin A Release

Elizabeth A. Coyle,1,2 Raymond Cha,1 and Michael J. Rybak1,3*

Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences,1 School of Medicine, Wayne State University, Detroit, Michigan 48201,3 University of Houston College of Pharmacy, Houston, Texas 770302

Received 21 March 2002/ Returned for modification 3 November 2002/ Accepted 7 February 2003

An in vitro model was used to compare the effects of linezolid, clindamycin, and penicillin, alone and in combination, on streptococcal pyrogenic exotoxin A (SPE A) release against virulent group A streptococci (GAS). All regimens exhibited lower (P < 0.05) SPE A release at 1 h than those with penicillin alone. Linezolid and clindamycin, alone or in combination with penicillin, may optimize the treatment of GAS infections by reducing bacterial burden and exotoxin release.

* Corresponding author. Mailing address: Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201. Phone: (313) 577-4376. Fax: (313) 577-8915. E-mail: m.rybak{at}wayne.edu.

Antimicrobial Agents and Chemotherapy, May 2003, p. 1752-1755, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1752-1755.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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