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Antimicrobial Agents and Chemotherapy, May 2003, p. 1766-1770, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1766-1770.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Use of High-Performance Liquid Chromatography To Study the Pharmacokinetics of Colistin Sulfate in Rats following Intravenous Administration

Jian Li,1,{dagger} Robert W. Milne,1* Roger L. Nation,1,{dagger} John D. Turnidge,2 Timothy C. Smeaton,3 and Kingsley Coulthard4

Centre for Pharmaceutical Research,1 School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide,3 Department of Microbiology and Infectious Diseases,2 Department of Pharmacy, Women's and Children's Hospital, North Adelaide, Australia4

Received 10 April 2002/ Returned for modification 3 October 2002/ Accepted 3 February 2003

The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.

* Corresponding author. Mailing address: Centre for Pharmaceutical Research, School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide SA 5000, Australia. Phone: 61 8 8302 2335. Fax: 61 8 8302 2389. E-mail: Robert.Milne{at}unisa.edu.au.

{dagger} Present address: Department of Pharmacy Practice, Victorian College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia.

Antimicrobial Agents and Chemotherapy, May 2003, p. 1766-1770, Vol. 47, No. 5
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.5.1766-1770.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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