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Antimicrobial Agents and Chemotherapy, June 2003, p. 1832-1835, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1832-1835.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antimicrobial Resistance of Invasive Pneumococci in Finland in 1999-2000

Marja Pihlajamäki,1* Jari Jalava,1 Pentti Huovinen,1 Pirkko Kotilainen,1,2 and the Finnish Study Group for Antimicrobial Resistance{dagger}

Antimicrobial Research Laboratory, National Public Health Institute,1 Department of Medicine, Turku University Central Hospital, Turku, Finland2

Received 29 October 2002/ Returned for modification 18 January 2003/ Accepted 16 March 2003

The resistance patterns and macrolide resistance mechanisms of 910 Finnish invasive pneumococci isolated during 1999 and 2000 were studied. Macrolide resistance was detected in 6.9% of isolates. Penicillin resistance was detected in 1.5% of isolates, and penicillin intermediate resistance was detected in 4.0% of isolates. Active macrolide efflux, mediated by the mef(A) gene, was the most common macrolide resistance mechanism. Four macrolide-resistant isolates had mutations in rRNA or ribosomal protein L22.

* Corresponding author. Mailing address: National Public Health Institute, Kiinamyllynkatu 13, 20520 Turku, Finland. Phone: 358-2-2519255. Fax: 358-2-2519254. E-mail: mapihla{at}utu.fi.

{dagger} Members of the Finnish Study Group on Antimicrobial Resistance are listed in Acknowledgments.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1832-1835, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1832-1835.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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