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Antimicrobial Agents and Chemotherapy, June 2003, p. 1902-1906, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1902-1906.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Linezolid Combined with Other Antimicrobial Agents against Staphylococci, Enterococci, Pneumococci, and Selected Gram-Negative Organisms

Michael T. Sweeney* and Gary E. Zurenko

Infectious Diseases Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007

Received 25 November 2002/ Returned for modification 27 January 2003/ Accepted 26 February 2003

The activities of linezolid, an oxazolidinone antibacterial agent active against gram-positive organisms, alone and in combination with 35 antimicrobial agents were tested in vitro against methicillin-sensitive (n = 1 to 2 strains) and methicillin-resistant (n = 8 to 10) Staphylococcus aureus strains; vancomycin-sensitive (n = 6) and vancomycin-resistant (n = 6 to 8) Enterococcus faecalis strains; vancomycin-sensitive (n = 5) and vancomycin-resistant (n = 6) Enterococcus faecium strains; penicillin-sensitive (n = 2 to 5), penicillin-intermediate (n = 5 to 6), and penicillin-resistant (n = 5 to 6) Streptococcus pneumoniae strains; Escherichia coli (n = 6); and Klebsiella pneumoniae (n = 6). The fractional inhibitory concentration indices of linezolid in combination with other antimicrobial agents for the organisms tested were generated on checkerboard broth microdilution plates prepared by a semiautomated method. Of 1,380 organism-drug combinations, 1,369 (99.2%) combinations of linezolid with 28 antimicrobial drugs were indifferent, 9 combinations (0.65%) of linezolid with 6 drugs (amoxicillin, erythromycin, imipenem, sparfloxacin, teicoplanin, and tetracycline) were synergistic, and 2 combinations (0.15%) of linezolid with 2 drugs (ofloxacin and sparfloxacin) were antagonistic. Overall, the in vitro data demonstrated that linezolid combined with other antimicrobial agents primarily produces an indifferent response, with infrequent occurrences of synergism and antagonism.

* Corresponding author. Mailing address: Pharmacia Corporation, 301 Henrietta St., 7263-267-504, Kalamazoo, MI 49007. Phone: (269) 833-3413. Fax: (269) 833-0992. E-mail: michael.t.sweeney{at}pharmacia.com.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1902-1906, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1902-1906.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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