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Antimicrobial Agents and Chemotherapy, June 2003, p. 1958-1962, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1958-1962.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

High Prevalence of Antimicrobial Resistance in Rapidly Growing Mycobacteria in Taiwan

Shun-Cheng Yang,1,2,{dagger} Po-Ren Hsueh,1,3* Hsin-Chih Lai,1,4 Lee-Jene Teng,1,4 Li-Min Huang,2 Jong-Min Chen,1,2 Shu-Kuan Wang,1 Der-Chuen Shie,1 Shen-Wu Ho,1,4 and Kwen-Tay Luh1,3

Departments of Laboratory Medicine,1 Pediatrics,2 Internal Medicine, National Taiwan University Hospital,3 School of Medical Technology, National Taiwan University College of Medicine, Taipei, Taiwan4

Received 7 October 2002/ Returned for modification 14 November 2002/ Accepted 24 February 2003

An increasing number of clinical isolations of rapidly growing mycobacteria (RGM) at the National Taiwan University Hospital were noted from 1992 to 2001. Broth microdilution MICs of 15 antimicrobial agents were determined for 200 clinical isolates of RGM, including the Mycobacterium fortuitum group (69 isolates), M. chelonae (39 isolates), and M. abscessus (92 isolates). Our results showed that the resistance rates of these isolates to the currently available agents were remarkably high. Amikacin was active against nearly all RGM isolates. Clarithromycin was usually active against M. abscessus (79% susceptibility) and the M. fortuitum group (65% susceptibility). The majority of M. fortuitum group isolates were susceptible to ciprofloxacin (62%) and imipenem (61%). The susceptibilities to other conventional anti-RGM agents of these isolates were poor but differed markedly by species. The newer fluoroquinolones (levofloxacin, moxifloxacin, and gatifloxacin) and meropenem showed better in vitro activities against the M. fortuitum group isolates than against the other two species of RGM. Linezolid had fairly good activity against these RGM isolates, particularly against M. chelonae isolates (82% susceptible). Telithromycin had poor activity against these RGM isolates (the MICs at which 50% of the isolates tested are inhibited [MIC50s] were 32 to 64 µg/ml, and the MIC90s were >64 µg/ml).

* Corresponding author. Mailing address: Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Rd., Taipei, Taiwan. Phone: 886-2-23123456, ext. 5363. Fax: 886-2-23224263. E-mail: hsporen{at}ha.mc.ntu.edu.tw.

{dagger} Present address: Department of Pediatrics, Changhua Christian Hospital, Changhua, Taiwan.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1958-1962, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1958-1962.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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