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Antimicrobial Agents and Chemotherapy, June 2003, p. 1968-1971, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1968-1971.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Dalbavancin and Nine Comparator Agents against Anaerobic Gram-Positive Species and Corynebacteria

Ellie J. C. Goldstein,1,2* Diane M. Citron,1 C. Vreni Merriam,1 Yumi Warren,1 Kerin Tyrrell,1 and Helen T. Fernandez1

R. M. Alden Research Laboratory, Santa Monica, California 90404,1 University of California at Los Angeles School of Medicine, Los Angeles, California 900732

Received 17 October 2002/ Returned for modification 21 February 2003/ Accepted 10 March 2003

Dalbavancin is a novel semisynthetic glycopeptide with enhanced activity against gram-positive species. Its comparative in vitro activities and those of nine comparator agents, including daptomycin, vancomycin, linezolid, and quinupristin-dalfopristin, against 290 recent gram-positive clinical isolates strains, as determined by the NCCLS agar dilution method, were studied. The MICs of dalbavancin at which 90% of various isolates tested were inhibited were as follows: Actinomyces spp., 0.5 µg/ml; Clostridium clostridioforme, 8 µg/ml; C. difficile, 0.25 µg/ml; C. innocuum, 0.25 µg/ml; C. perfringens, 0.125 µg/ml; C. ramosum, 1 µg/ml; Eubacterium spp., 1 µg/ml; Lactobacillus spp., >32 µg/ml, Propionibacterium spp., 0.5 µg/ml; and Peptostreptococcus spp., 0.25 µg/ml. Dalbavancin was 1 to 3 dilutions more active than vancomycin against most strains. Dalbavancin exhibited excellent activity against gram-positive strains tested and warrants clinical evaluation.

* Corresponding author. Mailing address: 2021 Santa Monica Blvd., Ste. 740 East, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: EJCGMD{at}aol.com.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1968-1971, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1968-1971.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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