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Antimicrobial Agents and Chemotherapy, June 2003, p. 1972-1975, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1972-1975.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Chlamydia pneumoniae Resists Antibiotics in Lymphocytes

Hiroyuki Yamaguchi,1 Herman Friedman,1 Mayumi Yamamoto,2 Keigo Yasuda,2 and Yoshimasa Yamamoto1,3*

Department of Medical Microbiology and Immunology, College of Medicine, University of South Florida, Tampa, Florida 33612,1 Third Department of Internal Medicine, School of Medicine, Gifu University, Gifu,2 Division of Molecular Microbiology, Department of Basic Laboratory Sciences, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Osaka, Japan3

Received 16 September 2002/ Returned for modification 11 February 2003/ Accepted 24 February 2003

Chlamydia pneumoniae infection of lymphocytes in blood has been well documented, and it is apparent that control of this pathogen in these cells may be critical in the development of chronic inflammatory diseases associated with infection by this bacterium. The activity of antibiotics against C. pneumoniae in lymphocytes was assessed in this study by utilizing an in vitro infection model with lymphoid cells. The results obtained indicated that although all of the antibiotics tested showed remarkable activity against bacterial growth in epithelial cells, C. pneumoniae in lymphocytes was less susceptible to antibiotics than was bacterial growth in epithelial cells, which are widely used for the evaluation of anti-C. pneumoniae antibiotics.

* Corresponding author. Mailing address: Division of Molecular Microbiology, Department of Basic Laboratory Sciences, School of Allied Health Sciences, Faculty of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-2580. Fax: 81-6-6879-2499. E-mail: yyamamot{at}sahs.med.osaka-u.ac.jp.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1972-1975, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1972-1975.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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