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Antimicrobial Agents and Chemotherapy, June 2003, p. 1976-1978, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1976-1978.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Lack of Vancomycin Tolerance in Streptococcus pneumoniae Strains Isolated in Barcelona, Spain, from 1999 to 2001

Mar Ortega,1* Francesc Marco,2 Alex Soriano,1 Elisa García,1 José A. Martínez,1 and Josep Mensa1

Infectious Diseases Unit,1 Microbiology Department, Institute of Infectious Diseases and Immunology, Hospital Clínic, Barcelona, Spain2

Received 21 November 2002/ Returned for modification 31 December 2002/ Accepted 7 March 2003

To evaluate the incidence of vancomycin tolerance among Streptococcus pneumoniae isolates, we performed killing curve studies with 633 isolates. The penicillin MIC was >=0.12 mg/liter for 481 (76%) of the isolates. All strains were susceptible to vancomycin. Killing curve studies were performed with a vancomycin concentration of 2.5 mg/liter. The Tupelo strain was used for quality control. No vancomycin-tolerant strain was detected.

* Corresponding author. Mailing address: Infectious Diseases Unit, Hospital Clínic, Escalera 9, 4° piso, Villarroel 170, 08036 Barcelona, Spain. Phone and fax: 34-93 2275529. E-mail: marortegaromero{at}yahoo.es.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1976-1978, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1976-1978.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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