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Antimicrobial Agents and Chemotherapy, June 2003, p. 1979-1983, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1979-1983.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

RNA III Inhibiting Peptide Inhibits In Vivo Biofilm Formation by Drug-Resistant Staphylococcus aureus

Andrea Giacometti,1 Oscar Cirioni,1 Yael Gov,2 Roberto Ghiselli,3 Maria Simona Del Prete,1 Federico Mocchegiani,3 Vittorio Saba,3 Fiorenza Orlando,4 Giorgio Scalise,1 Naomi Balaban,2 and Giorgio Dell'Acqua5*

Institute of Infectious Diseases and Public Health,1 Department of General Surgery, Istituto Nazionale Riposo e Cura Anziani, Istituto di Ricovero e Cura a Carattere Scientifico, University of Ancona,3 Biotechnology Centre, Research Department, Istituto Nazionale Riposo e Cura Anziani, Istituto di Ricovero e Cura a Carattere Scientifico, Ancona, Italy,4 Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel,2 Laboratoires Biologiques Arval SA, Conthey, Switzerland5

Received 12 August 2002/ Returned for modification 18 January 2003/ Accepted 4 March 2003

Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) is known to inhibit S. aureus pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability to inhibit S. aureus biofilm formation in a rat Dacron graft model. The activity of RIP was synergistic with those of antibiotics for the complete prevention of drug-resistant S. aureus infections.

* Corresponding author. Mailing address: Laboratoires Biologiques Arval SA, rue des Peupliers, 2, 1964 Conthey, Switzerland. Phone: 41-27-3454565. Fax: 41-27-3454560. E-mail: g.dellacqua{at}arval.ch.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1979-1983, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1979-1983.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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