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Antimicrobial Agents and Chemotherapy, June 2003, p. 1991-1994, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1991-1994.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Stability and Antibacterial Activity of Cefepime during Continuous Infusion

University of Oslo, Oslo, Norway,¹ University of Southern California, Los Angeles,² City of Hope, Duarte, California³

Received 3 October 2002/ Returned for modification 23 January 2003/ Accepted 18 March 2003

The stability of cefepime during simulated continuous infusion was determined with a motorized portable infusion pump worn over a period of 24 to 36 h. Susceptibility testing on cefepime solutions over time indicates that the degradation products do not exhibit antibacterial activity. Cefepime stability at 24 h following continuous infusion was 94.3% ± 1.0%, which supports the use of continuous infusion.

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