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Antimicrobial Agents and Chemotherapy, June 2003, p. 1995-1998, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1995-1998.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Killing Activity of Micafungin against Aspergillus fumigatus Hyphae Assessed by Specific Fluorescent Staining for Cell Viability

Etsuko Watabe,* Toru Nakai, Satoru Matsumoto, Fumiaki Ikeda, and Kazuo Hatano

Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Yodogawa-ku, Osaka 532-8514, Japan

Received 15 November 2002/ Returned for modification 27 December 2002/ Accepted 14 February 2003

We studied the anti-Aspergillus activity of micafungin by using two fluorescent dyes to detect cell viability. Micafungin induced flattened hyphae, caused by the bursting of cells, which had lost their viability. Micafungin has killing activity against actively growing hyphae, even though it is not fungicidal against the whole burden of Aspergillus fumigatus.

* Corresponding author. Mailing address: Department of Infectious Diseases, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 1-6 Kashima 2-chome, Yodogawa-ku, Osaka, 532-8514, Japan. Phone: 81 6 6390 1158. Fax: 81 6 6304 5367. E-mail: etsuko_watabe{at}po.fujisawa.co.jp.

Antimicrobial Agents and Chemotherapy, June 2003, p. 1995-1998, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.1995-1998.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sucher, A. J, Chahine, E. B, Balcer, H. E (2009). Echinocandins: The Newest Class of Antifungals. The Annals of Pharmacotherapy 43: 1647-1657 [Abstract] [Full Text]  
  • Steinbach, W. J., Cramer, R. A. Jr., Perfect, B. Z., Henn, C., Nielsen, K., Heitman, J., Perfect, J. R. (2007). Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus. Antimicrob. Agents Chemother. 51: 2979-2981 [Abstract] [Full Text]  
  • Carver, P. L (2004). Micafungin. The Annals of Pharmacotherapy 38: 1707-1721 [Abstract] [Full Text]  


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