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Antimicrobial Agents and Chemotherapy, June 2003, p. 2009-2011, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2009-2011.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates in Lithuania

Laboratory of Immunology, Institute of Biotechnology, Vilnius 2028,¹ National Tuberculosis Reference Laboratory, The Republican Hospital of Tuberculosis and Lung Diseases, Vilnius 2040, Lithuania²

Received 21 October 2002/ Returned for modification 30 December 2002/ Accepted 10 March 2003

Mutations at codon 315 of the katG gene were detected in 312 of 364 (85.7%) isoniazid-resistant Mycobacterium tuberculosis isolates. Seven of 52 (13.5%) isoniazid-resistant isolates with the wild-type Ser315 codon and 10 of 52 (19.2%) isoniazid-resistant isolates with a mutated katG allele had mutation -15CT in the promoter of the mabA-inhA operon.

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