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Antimicrobial Agents and Chemotherapy, June 2003, p. 2015-2017, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2015-2017.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Vancomycin Penetration of Uninfected Pleural Fluid Exudate after Continuous or Intermittent Infusion

Baudouin Byl,1* Frédérique Jacobs,1 Pierre Wallemacq,2 Camelia Rossi,1 Philippe de Francquen,3 Matteo Cappello,3 Teresinha Leal,2 and Jean-Pierre Thys1

Infectious Diseases Clinic,1 Thoracic Surgery Department, Erasme University Hospital, Université Libre de Bruxelles,3 Clinical Chemistry Department, Saint-Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium2

Received 18 July 2002/ Returned for modification 30 December 2002/ Accepted 4 March 2003

Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).

* Corresponding author. Mailing address: Infectious Diseases Clinic, Erasme University Hospital, Route de Lennik 808, B-1070 Brussels, Belgium. Phone: 32 2 5556746. Fax: 32 2 5553912. E-mail: baudouin.byl{at}ulb.ac.be.

Antimicrobial Agents and Chemotherapy, June 2003, p. 2015-2017, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2015-2017.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Weiler, S., Bellmann-Weiler, R., Joannidis, M., Bellmann, R. (2007). Penetration of Amphotericin B Lipid Formulations into Pleural Effusion. Antimicrob. Agents Chemother. 51: 4211-4213 [Abstract] [Full Text]  
  • de Jesus Valle, M. J., Lopez, F. G., Hurle, A. D.-G., Navarro, A. S. (2007). Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung. Antimicrob. Agents Chemother. 51: 3771-3774 [Abstract] [Full Text]  


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