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Antimicrobial Agents and Chemotherapy, June 2003, p. 2022-2026, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2022-2026.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Alpha Interferon Augments Cidofovir's Antiviral and Antiproliferative Activities

Jeffrey A. Johnson* and J. David Gangemi

Department of Microbiology and Molecular Medicine and the Greenville Hospital System Biomedical Cooperative, Clemson University, Clemson, South Carolina 29634

Received 4 October 2002/ Returned for modification 30 December 2002/ Accepted 6 February 2003

The antiviral and antiproliferative activities of alpha 2a interferon (IFN-{alpha}2a) and cidofovir in human papillomavirus type 16 (HPV-16)-transformed keratinocytes were evaluated. The compounds in combination were more effective than comparable levels of either drug alone. Evaluation of effective drug ratios revealed a synergistic cooperation between IFN-{alpha}2a and cidofovir in inhibiting the proliferation of HPV-infected cells.

* Corresponding author. Present address: Centers for Disease Control and Prevention, NCID/DASTLR/HARB, Bldg. 15, MS G19, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-4976. Fax: (404) 639-1174. E-mail: jjohnson1{at}cdc.gov.

Antimicrobial Agents and Chemotherapy, June 2003, p. 2022-2026, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2022-2026.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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Copyright © 2003 by the American Society for Microbiology. All rights reserved.