This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ASM journals
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Crémieux, A.-C.
Right arrow Articles by Andremont, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Crémieux, A.-C.
Right arrow Articles by Andremont, A.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2003, p. 2030-2035, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2030-2035.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Emergence of Resistance in Normal Human Aerobic Commensal Flora during Telithromycin and Amoxicillin-Clavulanic Acid Treatments

Anne-Claude Crémieux,1 Claudette Muller-Serieys,2 Xavière Panhard,3 Frédérique Delatour,1 Marina Tchimichkian,4 France Mentre,3 and Antoine Andremont2*

Laboratory of Bacteriology, EMI-U 9933,2 Clinical Investigation Center,1 Department of Epidemiology and Biostatistics, Bichat-Claude Bernard Hospital,3 Microbiology Laboratory, Ambroise-Paré Hospital, Paris, France4

Received 13 September 2002/ Returned for modification 9 December 2002/ Accepted 5 March 2003

Mean fecal global yeast counts increased similarly during 7 days of treatment with telithromycin (800 mg once daily) or amoxicillin-clavulanic acid (amoxiclav) (1 g of amoxicillin and 125 mg of clavulanic acid 3 times daily) in human volunteers and decreased slowly thereafter. On skin, coagulase-negative staphylococci of decreased susceptibility (DS) to telithromycin increased in the telithromycin group, whereas those with DS to methicillin increased in the amoxiclav group. A similar antibiotic-related shift towards homologous DS was observed for oral nongroupable streptococci (NGS), but in addition, the prevalence of NGS resistant to both classes of antibiotics was significantly greater in the amoxiclav group at days 8 (P < 0.01) and 45 (P < 0.015).

* Corresponding author. Mailing address: Laboratory of Bacteriology, Bichat Claude Bernard Hospital, 46, rue Henri Huchard, 75018 Paris, France. Phone: 33 1 40 25 85 01. Fax: 33 1 40 25 85 81. E-mail: antoine.andremont{at}bch.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, June 2003, p. 2030-2035, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2030-2035.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chardin, H., Yasukawa, K., Nouacer, N., Plainvert, C., Aucouturier, P., Ergani, A., Descroix, V., Toledo-Arenas, R., Azerad, J., Bouvet, A. (2009). Reduced susceptibility to amoxicillin of oral streptococci following amoxicillin exposure. J Med Microbiol 58: 1092-1097 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»