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Antimicrobial Agents and Chemotherapy, June 2003, p. 2036-2039, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2036-2039.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Resistance to Autolysis in Vancomycin-Selected Staphylococcus aureus Isolates Precedes Vancomycin-Intermediate Resistance

Susan Boyle-Vavra,1* Mamatha Challapalli,1 and Robert S. Daum1,2,3

Department of Pediatrics,1 Committees on Microbiology,2 Molecular Medicine, The University of Chicago, Chicago, Illinois 606373

Received 17 September 2002/ Returned for modification 13 December 2002/ Accepted 9 February 2003

Four clinical U.S. glycopeptide intermediate resistant Staphylococcus aureus (GISA) isolates were resistant to Triton X-100-induced autolysis. Similar resistance was demonstrated in an isolate obtained after a single passage of a susceptible clinical isolate in low-level vancomycin. Strains with the vancomycin-induced Triton X-100 resistance phenotype produced active murein hydrolases but were resistant to lysis by murein hydrolases.

* Corresponding author. Mailing address: Department of Pediatrics, The University of Chicago, 5841 S. Maryland Ave., MC 6054, Chicago, IL 60637. Phone: (773) 702-6401. Fax: (773) 702-1196. E-mail: sboyleva{at}midway.uchicago.edu.

Antimicrobial Agents and Chemotherapy, June 2003, p. 2036-2039, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2036-2039.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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