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Antimicrobial Agents and Chemotherapy, June 2003, p. 2040-2042, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2040-2042.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Biochemical Characterization of ß-Lactamases Bla1 and Bla2 from Bacillus anthracis

Isabel C. Materon,1 Anne Marie Queenan,2 Theresa M. Koehler,3 Karen Bush,2 and Timothy Palzkill1*

Department of Molecular Virology and Microbiology, Baylor College of Medicine,1 Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas 77030,3 Johnson & Johnson Pharmaceutical Research and Development, Raritan, New Jersey 088692

Received 17 December 2002/ Returned for modification 30 January 2003/ Accepted 7 March 2003

The Sterne and Ames strains of Bacillus anthracis carry chromosomal genes bla1 and bla2, which confer ß-lactam resistance when expressed in Escherichia coli. MIC measurements and steady-state kinetic analyses indicate that Bla1 possesses penicillinase activity while Bla2 possesses penicillinase, cephalosporinase, and carbapenem-hydrolyzing activities.

* Corresponding author. Mailing address: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Cullen 244A, Houston, TX 77030. Phone: (713) 798-5609. Fax: (713) 798-7375. E-mail: timothyp{at}bcm.tmc.edu.

Antimicrobial Agents and Chemotherapy, June 2003, p. 2040-2042, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2040-2042.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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