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Antimicrobial Agents and Chemotherapy, June 2003, p. 2051-2055, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2051-2055.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Inhibitors of Pantothenate Kinase: Novel Antibiotics for Staphylococcal Infections

Anthony E. Choudhry,1 Tracy L. Mandichak,1,{dagger} John P. Broskey,1 Richard W. Egolf,1,{dagger} Cynthia Kinsland,2 Tadhg P. Begley,2 Mark A. Seefeld,1 Thomas W. Ku,1 James R. Brown,1* Magdalena Zalacain,1 and Kapila Ratnam1*

Microbial, Musculoskeletal and Proliferative Diseases and Bioinformatics, GlaxoSmithKline Pharmaceuticals, Collegeville Pennsylvania 19426,1 Department of Chemistry and Chemical Biology, Cornell University, Ithaca New York 148502

Received 22 November 2002/ Returned for modification 20 January 2003/ Accepted 28 February 2003

Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.

* Corresponding author. Mailing address: Microbial, Musculoskeletal and Proliferative Diseases and Bioinformatics, GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Rd., Collegeville, PA 19426. Phone: (610) 917-6399. Fax: (610) 917-7901. E-mail for James R. Brown: james.r.brown{at}gsk.com. E-mail for Kapila Ratnam: kapila.2.ratnam{at}gsk.com.

{dagger} Present address: The Pennsylvania State University, Eberly College of Science, University Park, PA 16802-6004.

Antimicrobial Agents and Chemotherapy, June 2003, p. 2051-2055, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2051-2055.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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