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Antimicrobial Agents and Chemotherapy, June 2003, p. 2051-2055, Vol. 47, No. 6
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.6.2051-2055.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Inhibitors of Pantothenate Kinase: Novel Antibiotics for Staphylococcal Infections

Anthony E. Choudhry,¹ Tracy L. Mandichak,^1, John P. Broskey,¹ Richard W. Egolf,^1, Cynthia Kinsland,² Tadhg P. Begley,² Mark A. Seefeld,¹ Thomas W. Ku,¹ James R. Brown,^1* Magdalena Zalacain,¹ and Kapila Ratnam^1*

Microbial, Musculoskeletal and Proliferative Diseases and Bioinformatics, GlaxoSmithKline Pharmaceuticals, Collegeville Pennsylvania 19426,¹ Department of Chemistry and Chemical Biology, Cornell University, Ithaca New York 14850²

Received 22 November 2002/ Returned for modification 20 January 2003/ Accepted 28 February 2003

Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.

Present address: The Pennsylvania State University, Eberly College of Science, University Park, PA 16802-6004.

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