This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buckwold, V. E.
Right arrow Articles by Russell, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buckwold, V. E.
Right arrow Articles by Russell, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, July 2003, p. 2293-2298, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2293-2298.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Synergistic In Vitro Interactions between Alpha Interferon and Ribavirin against Bovine Viral Diarrhea Virus and Yellow Fever Virus as Surrogate Models of Hepatitis C Virus Replication

Victor E. Buckwold,* Jiayi Wei, Michelle Wenzel-Mathers, and Julie Russell

Infectious Disease Research Department, Southern Research Institute, Frederick, Maryland

Received 28 October 2002/ Returned for modification 17 January 2003/ Accepted 7 April 2003

Monotherapy of hepatitis C virus infection with either alpha interferon or ribavirin alone is rather ineffective, while the use of the two antivirals together is much more efficacious. In vitro drug-drug combination analysis utilizing related members of the family Flaviviridae, bovine viral diarrhea virus and yellow fever virus, revealed significant direct synergistic interactions between these drugs' antiviral activities that might explain this clinical observation.

* Corresponding author. Mailing address: Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701. Phone: (301) 694-3232. Fax (301) 694-7223. E-mail: Buckwold{at}sri.org.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2293-2298, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2293-2298.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • SBRANA, E., XIAO, S.-Y., GUZMAN, H., YE, M., TRAVASSOS DA ROSA, A. P. A., TESH, R. B. (2004). EFFICACY OF POST-EXPOSURE TREATMENT OF YELLOW FEVER WITH RIBAVIRIN IN A HAMSTER MODEL OF THE DISEASE. Am J Trop Med Hyg 71: 306-312 [Abstract] [Full Text]  
  • Buckwold, V. E. (2004). Implications of finding synergic in vitro drug-drug interactions between interferon-{alpha} and ribavirin for the treatment of hepatitis C virus. J Antimicrob Chemother 53: 413-414 [Abstract] [Full Text]  
  • Durantel, D., Carrouee-Durantel, S., Branza-Nichita, N., Dwek, R. A., Zitzmann, N. (2004). Effects of Interferon, Ribavirin, and Iminosugar Derivatives on Cells Persistently Infected with Noncytopathic Bovine Viral Diarrhea Virus. Antimicrob. Agents Chemother. 48: 497-504 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»