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Antimicrobial Agents and Chemotherapy, July 2003, p. 2293-2298, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2293-2298.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Synergistic In Vitro Interactions between Alpha Interferon and Ribavirin against Bovine Viral Diarrhea Virus and Yellow Fever Virus as Surrogate Models of Hepatitis C Virus Replication

Victor E. Buckwold,* Jiayi Wei, Michelle Wenzel-Mathers, and Julie Russell

Infectious Disease Research Department, Southern Research Institute, Frederick, Maryland

Received 28 October 2002/ Returned for modification 17 January 2003/ Accepted 7 April 2003

Monotherapy of hepatitis C virus infection with either alpha interferon or ribavirin alone is rather ineffective, while the use of the two antivirals together is much more efficacious. In vitro drug-drug combination analysis utilizing related members of the family Flaviviridae, bovine viral diarrhea virus and yellow fever virus, revealed significant direct synergistic interactions between these drugs' antiviral activities that might explain this clinical observation.

* Corresponding author. Mailing address: Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701. Phone: (301) 694-3232. Fax (301) 694-7223. E-mail: Buckwold{at}sri.org.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2293-2298, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2293-2298.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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