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Antimicrobial Agents and Chemotherapy, July 2003, p. 2299-2302, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2299-2302.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Inhibitory Effect of NO-Releasing Ciprofloxacin (NCX 976) on Mycobacterium tuberculosis Survival

R. Ciccone,1 F. Mariani,2 A. Cavone,1 T. Persichini,3 G. Venturini,3 E. Ongini,4 V. Colizzi,1 and M. Colasanti3*

Department of Biology, University of Rome "Tor Vergata,",1 Institute of Neurobiology and Molecular Medicine, National Council of Research,2 Department of Biology University of Rome "Roma Tre," Rome,3 Nicox Research Institute, Bresso, Milan, Italy4

Received 18 June 2002/ Returned for modification 29 July 2002/ Accepted 21 March 2003

Here, we report the antimycobacterial activity of NCX 976, a new molecule obtained adding a NO moiety to the fluoroquinolone ciprofloxacin, on Mycobacterium tuberculosis H37Rv strain, both in a cell-free model and in infected human macrophages. Unlike unaltered ciprofloxacin, NCX976 displayed a marked activity also at low-nanomolar concentrations.

* Corresponding author. Mailing address: Department of Biology, University "ROMA TRE," Viale Marconi, 446, I-00146 Rome, Italy. Phone: 39 06 55176342. Fax: 39 06 55176383. E-mail: colasant{at}uniroma3.it.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2299-2302, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2299-2302.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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