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Antimicrobial Agents and Chemotherapy, July 2003, p. 2303-2306, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2303-2306.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Intracellular Release of Nitric Oxide by NCX 972, an NO-Releasing Metronidazole, Enhances In Vitro Killing of Entamoeba histolytica

Anna Sannella,1 Luigi Gradoni,1 Tiziana Persichini,2 Ennio Ongini,3 Giorgio Venturini,2 and Marco Colasanti2*

Laboratory of Parasitology, Istituto Superiore di Sanità,1 Department of Biology, University of Rome "Roma Tre," Rome,2 Nicox Research Institute, Bresso, Milan, Italy3

Received 23 December 2002/ Returned for modification 30 January 2003/ Accepted 24 March 2003

The activity of NCX 972, a new molecule obtained by adding a nitric oxide (NO) moiety to metronidazole, was tested against six isolates of Entamoeba histolytica in xenic cultures. NCX 972 released NO into trophozoite cells and enhanced killing of amoebas in a dose- and time-dependent manner compared to metronidazole.

* Corresponding author. Mailing address: Department of Biology, University "ROMA TRE," Viale Marconi, 446, I-00146 Rome, Italy. Phone: 39 06 55176342. Fax: 39 06 55176383. E-mail: colasant{at}uniroma3.it.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2303-2306, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2303-2306.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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