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Antimicrobial Agents and Chemotherapy, July 2003, p. 2313-2315, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2313-2315.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Zinc Eluted from Siliconized Latex Urinary Catheters Decreases OprD Expression, Causing Carbapenem Resistance in Pseudomonas aeruginosa

M. Carmen Conejo,1* Isabel García,1 Luis Martínez-Martínez,1 Leandro Picabea,2 and Álvaro Pascual1

Department of Microbiology, School of Medicine, University of Seville,1 Forensic Science Institute, Seville, Spain2

Received 3 January 2003/ Returned for modification 21 February 2003/ Accepted 26 March 2003

The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Seville, Apdo. 914, 41080 Seville, Spain. Phone: 34-954552862. Fax: 34-954377413. E-mail: cconejo{at}us.es.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2313-2315, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2313-2315.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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