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Antimicrobial Agents and Chemotherapy, July 2003, p. 2319-2322, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2319-2322.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Ribosomal Mutations Conferring Resistance to Macrolides in Streptococcus pneumoniae Clinical Strains Isolated in Germany

Institute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany,¹ Hershey Medical Center, Hershey, Pennsylvania²

Received 19 December 2002/ Returned for modification 12 March 2003/ Accepted 7 April 2003

Among a collection of 4,281 pneumococcal isolates, 7 strains isolated in Germany had an unusual macrolide resistance phenotype. The isolates were found to have multiple mutations in the 23S rRNA and alterations in the L4 ribosomal protein. One strain had an amino acid alteration in the L22 ribosomal protein.

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