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Antimicrobial Agents and Chemotherapy, July 2003, p. 2327-2329, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2327-2329.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Inhibitory Activities of Quinolones against DNA Gyrase of Chlamydia pneumoniae

Satoshi Ameyama,* Yuko Shinmura, and Masahiro Takahata

Research Laboratories, Toyama Chemical Co., Ltd., Toyama 930-8508, Japan,

Received 5 December 2002/ Returned for modification 7 January 2003/ Accepted 15 April 2003

The gyrA and gyrB genes of Chlamydia pneumoniae TW-183 were cloned, and their proteins were purified by use of a fusion system with a maltose-binding protein. The 50% inhibitory concentrations of garenoxacin, sparfloxacin, moxifloxacin, gatifloxacin, and levofloxacin were 10.1, 47.5, 39.6, 64.2, and 156.9 µg/ml, respectively, and the MICs against C. pneumoniae TW-183 were 0.008, 0.016, 0.063, 0.125, and 0.25 µg/ml, respectively.

* Corresponding author. Mailing address: Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1, Shimookui, Toyama 930-8508, Japan. Phone: 81-76-431-8268. Fax: 81-76-431-8208. E-mail: SATOSHI_AMEYAMA{at}toyama-chemical.co.jp.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2327-2329, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2327-2329.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Smith, R. P., Baltch, A. L., Ritz, W. J., Carpenter, A. N., Halse, T. A., Bopp, L. H. (2004). In Vitro Activities of Garenoxacin and Levofloxacin against Chlamydia pneumoniae Are Not Affected by Presence of Mycoplasma DNA. Antimicrob. Agents Chemother. 48: 2081-2084 [Abstract] [Full Text]  


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