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Antimicrobial Agents and Chemotherapy, July 2003, p. 2330-2333, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2330-2333.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Sfh-I, a Subclass B2 Metallo-ß-Lactamase from a Serratia fonticola Environmental Isolate

Maria José Saavedra,1 Luísa Peixe,2 João Carlos Sousa,2 Isabel Henriques,3 Artur Alves,3 and António Correia3*

Departmento de Higiene e Sanidade, ICETA, University of Trás-os-Montes e Alto Douro, Vila Real,1 Faculty of Pharmacy, University of Porto, Porto,2 Center for Cell Biology, University of Aveiro, Aveiro, Portugal3

Received 9 December 2002/ Returned for modification 10 January 2003/ Accepted 16 April 2003

An environmental isolate of Serratia fonticola resistant to carbapenems was shown to contain a genetic determinant encoding a metallo-ß-lactamase of the subclass B2. The Sfh-I enzyme exhibits some divergence from the previously characterized enzymes of this subclass. This is the first example of a naturally occurring metallo-ß-lactamase in Enterobacteriaceae.

* Corresponding author. Mailing address: Center for Cell Biology, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal. Phone: 351-234370778. Fax: 351-234426408. E-mail: acorreia{at}bio.ua.pt.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2330-2333, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2330-2333.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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