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Antimicrobial Agents and Chemotherapy, July 2003, p. 2345-2347, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2345-2347.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activity of Telithromycin against Penicillin-Resistant Streptococcus pneumoniae Isolates Recovered from French Children with Invasive and Noninvasive Infections

Edouard Bingen,1* Catherine Doit,1 Chawki Loukil,1 Naima Brahimi,1 Philippe Bidet,1 Dominique Deforche,1 and Pierre Geslin2

Service de Microbiologie, Hôpital Robert Debré, Paris,1 Service de Microbiologie, Hôpital Intercommunal de Créteil, Créteil, France2

Received 13 January 2003/ Returned for modification 24 March 2003/ Accepted 17 April 2003

We compared the activities of telithromycin, erythromycin, azithromycin, josamycin, penicillin G, amoxicillin, cefpodoxime, and ceftriaxone against invasive and noninvasive non-penicillin-susceptible Streptococcus pneumoniae isolates recovered from children. Of the 186 isolates tested, 89% were positive for erm(B) by PCR. Telithromycin had the lowest MICs, with MICs at which 90% of the isolates tested are inhibited of 0.032 and 0.25 µg/ml for erythromycin-sensitive and -resistant isolates, respectively.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital Robet Debré, 48 Bd. Sérurier, 75019 Paris, France. Phone: 33 1 40 03 23 40. Fax: 33 1 40 03 24 50. E-mail: edouard.bingen{at}rdb.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2345-2347, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2345-2347.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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