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Antimicrobial Agents and Chemotherapy, July 2003, p. 2348-2350, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2348-2350.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Development and Validation of a High-Performance Liquid Chromatography Assay for Voriconazole

Gennethel J. Pennick,1* Martin Clark,2 Deanna A. Sutton,1 and Michael G. Rinaldi1,3

Department of Pathology, University of Texas Health Science Center at San Antonio ,1 Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas,3 Pfizer Limited, Sandwich, United Kingdom2

Received 21 August 2002/ Returned for modification 26 January 2003/ Accepted 27 March 2003

An analytical method for the determination of voriconazole (UK-109,496; Pfizer) in plasma was developed and validated. The method utilizes solid-phase extraction technology and high-performance liquid chromatography. The lower limit of quantitation is 0.2 µg/ml, and the range of linearity tested was 0.2 to 10 µg/ml.

* Corresponding author. Mailing address: Department of Pathology, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900. Phone: (210) 567-4131. Fax: (210) 567-4076. E-mail: pennick{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2348-2350, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2348-2350.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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