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Antimicrobial Agents and Chemotherapy, July 2003, p. 2354-2357, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2354-2357.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Antimicrobial Susceptibility of Brachyspira pilosicoli Isolates from Humans

C. J. Brooke,1 D. J. Hampson,1 and T. V. Riley2,3*

Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150,1 Division of Microbiology and Infectious Diseases, Western Australian Centre of Pathology and Medical Research,2 Department of Microbiology, University of Western Australia, Nedlands, Western Australia 6009, Australia3

Received 4 November 2002/ Returned for modification 22 January 2003/ Accepted 3 April 2003

The in vitro antimicrobial susceptibility of the anaerobic intestinal spirochete Brachyspira pilosicoli was investigated by an agar dilution method. Human (n = 123) and porcine (n = 16) isolates were susceptible to metronidazole, ceftriaxone, meropenem, tetracycline, moxifloxacin, and chloramphenicol; erythromycin and ciprofloxacin were not active. Resistance to amoxicillin and clindamycin varied. Amoxicillin susceptibility was restored by clavulanic acid.

* Corresponding author. Mailing address: Department of Microbiology, University of Western Australia, Nedlands, Western Australia 6009, Australia. Phone: 61 8 9346 3690. Fax: 61 8 93462912. E-mail: triley {at}cyllene.uwa.edu.au.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2354-2357, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2354-2357.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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