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Antimicrobial Agents and Chemotherapy, July 2003, p. 2370-2372, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2370-2372.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Emergence of Macrolide Resistance in Throat Culture Isolates of Group A Streptococci in Ontario, Canada, in 2001

Kevin C. Katz,1,2 Allison J. McGeer,1,2 Carla L. Duncan,1 Aisha Ashi-Sulaiman,1 Barbara M. Willey,1 Alicia Sarabia,3 Jacquie McCann,3 Sylvia Pong-Porter,1 Yana Rzayev,1 Joyce S. de Azavedo,1,2 and Donald E. Low1,2*

Toronto Medical Laboratories/Mount Sinai Hospital Department of Microbiology,1 University of Toronto,2 MDS Laboratories, Toronto, Ontario, Canada3

Received 6 January 2003/ Returned for modification 25 March 2003/ Accepted 26 April 2003

Of 500 group A streptococci isolated from pharyngeal swabs, 72 (14.4%) were macrolide resistant, compared to 2.1% in 1997. Of these, 66 (92%) were of the M phenotype and 6 (8.3%) were of the MLS phenotype. Pulsed-field gel electrophoresis found that two clones, with patterns identical to those of serotypes M1 and M4, accounted for 19.4 and 68.1% of the macrolide-resistant isolates, respectively.

* Corresponding author. Mailing address: Department of Microbiology, Rm. 1483, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario, Canada M5G 1X5. Phone: (416) 586-4435. Fax: (416) 586-8746. E-mail: dlow{at}mtsinai.on.ca.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2370-2372, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2370-2372.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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