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Antimicrobial Agents and Chemotherapy, July 2003, p. 2373-2375, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2373-2375.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Addition of Caspofungin to Fluconazole Does Not Improve Outcome in Murine Candidiasis

John R. Graybill,1* Rosie Bocanegra,1 Laura K. Najvar,1 Steve Hernandez,1 and Robert A. Larsen2

The University of Texas Health Science Center at San Antonio Department of Medicine, Division of Infectious Diseases, San Antonio, Texas 78229-3900,1 Division of Infectious Diseases, Department of Medicine, University of Southern California, Los Angeles, California 900332

Received 20 February 2003/ Returned for modification 13 March 2003/ Accepted 10 April 2003

Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.

* Corresponding author. Mailing address: The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases (7881), 7703 Floyd Curl Dr., San Antonio, TX 78229-3900. Phone: (210) 567-0990. Fax: (210) 567-0962. E-mail: jrgraybill{at}aol.com.

Antimicrobial Agents and Chemotherapy, July 2003, p. 2373-2375, Vol. 47, No. 7
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.7.2373-2375.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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