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Reduced Release of Pneumolysin by Streptococcus pneumoniae In Vitro and In Vivo after Treatment with Nonbacteriolytic Antibiotics in Comparison to Ceftriaxone

Annette Spreer,¹ Holger Kerstan,¹ Tobias Böttcher,¹ Joachim Gerber,¹ Alexander Siemer,^2, Gregor Zysk,³ Timothy J. Mitchell,⁴ Helmut Eiffert,⁵ and Roland Nau^1*

Departments of Neurology,¹ Medical Statistics,² Bacteriology, University of Göttingen, Göttingen,⁵ Department of Medical Microbiology and Virology, University of Düsseldorf, Düsseldorf, Germany,³ Division of Infection and Immunity, University of Glasgow, Glasgow, Scotland⁴

Received 26 August 2002/ Returned for modification 14 February 2003/ Accepted 7 May 2003

Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.

Present address: Boehringer Ingelheim, Biberach an der Ries, Germany.

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