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Antimicrobial Agents and Chemotherapy, August 2003, p. 2649-2654, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2649-2654.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Reduced Release of Pneumolysin by Streptococcus pneumoniae In Vitro and In Vivo after Treatment with Nonbacteriolytic Antibiotics in Comparison to Ceftriaxone

Annette Spreer,1 Holger Kerstan,1 Tobias Böttcher,1 Joachim Gerber,1 Alexander Siemer,2,{dagger} Gregor Zysk,3 Timothy J. Mitchell,4 Helmut Eiffert,5 and Roland Nau1*

Departments of Neurology,1 Medical Statistics,2 Bacteriology, University of Göttingen, Göttingen,5 Department of Medical Microbiology and Virology, University of Düsseldorf, Düsseldorf, Germany,3 Division of Infection and Immunity, University of Glasgow, Glasgow, Scotland4

Received 26 August 2002/ Returned for modification 14 February 2003/ Accepted 7 May 2003

Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.

* Corresponding author. Mailing address: Department of Neurology, University Hospital, Robert-Koch-Str. 40, 37075 Göttingen, Germany. Phone: 49-551-398455. Fax: 49-551-398405. E-mail: rnau{at}gwdg.de.

{dagger} Present address: Boehringer Ingelheim, Biberach an der Ries, Germany.

Antimicrobial Agents and Chemotherapy, August 2003, p. 2649-2654, Vol. 47, No. 8
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.8.2649-2654.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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